Vol. 6, Issue 1, Part A (2024)

Vegetative pemphigus is a rare variety of deep pemphigus. Diagnosis is based on clinical, immunological, and histopathological patterns. Its occurrence during pregnancy is rare. We report 02 cases of vegetative pemphigus including one in pregnancy. It consisted of two women, aged 29 and 40 of old, respectively. One of them was 23 weeks pregnant. Both underwent vegetative lesions located at the large folds and in one of them, there were more than a hundred pustules next to the bullae. Nail damage was present in both patients and non-scarring alopecia. Histopathology was in favor of deep pemphigus. A Hallopeau-like form was retained in one of the patients, contrasting with mucosal involvement. Treatment with corticosteroids was associated with Dapsone in one case due to corticosteroid resistance. Regarding the pregnant woman, the evolution was favorable with a cesarean delivery at 32 weeks + 2 days, of a premature newborn free of any skin lesion. Recurrences were triggered by infections: bacterial dermohypodermitis and vulvovaginitis.