Vol. 6, Issue 1, Part A (2024)

To evaluate the therapy of hypertrophic and keloid scars using the locally applied commercial cream known as SODERMIX, developed with a high concentration of superoxide dismutase (SOD). SODERMIX cream exhibits qualities as an antioxidant, anti-inflammatory, anti-fibrotic, and anti-pruritic agent. This study was conducted on 40 patients with either new or old scars from burns and surgery, and some with small open wounds. These patients applied SODERMIX cream topically twice daily, supplemented with intralesional steroid injections where necessary. The study showed an overall improvement in scar appearance, decreased itching, and reduced pigmentation. The cream was found to prevent fibrosis, reduce myofibroblast density, and support extracellular matrix remodeling. Thus, SODERMIX cream shows potential in managing hypertrophic and keloid scars effectively. (Burns, 2024; Journal of Dermatological Treatment, 2024) (Plastic and Reconstructive Surgery, 2024).